TXA should be administered within how many hours of hemorrhage onset?

TXA should be administered within how many hours of hemorrhage onset?

• A. 1 hour
• B. 3 hours
• C. 6 hours
• D. 12 hours

Answer: (B)

Timing is everything with tranexamic acid in hemorrhage. TXA works by inhibiting fibrinolysis, helping to stabilize clots and reduce ongoing bleeding. Evidence shows the greatest, most consistent mortality benefit when TXA is given as soon as bleeding starts, with the advantage strongest if administered within three hours. After that window, the benefit wanes and the risk-to-benefit balance becomes less favorable. In practice, TXA is given promptly (commonly 1 g IV over 10 minutes, then 1 g over 8 hours) once hemorrhage is recognized, provided there are no contraindications.

Timing is everything with tranexamic acid in hemorrhage. TXA works by inhibiting fibrinolysis, helping to stabilize clots and reduce ongoing bleeding. Evidence shows the greatest, most consistent mortality benefit when TXA is given as soon as bleeding starts, with the advantage strongest if administered within three hours. After that window, the benefit wanes and the risk-to-benefit balance becomes less favorable. In practice, TXA is given promptly (commonly 1 g IV over 10 minutes, then 1 g over 8 hours) once hemorrhage is recognized, provided there are no contraindications.