Which condition is considered a contraindication to TXA use?

Which condition is considered a contraindication to TXA use?

• A. Active clotting disorders
• B. Hypertension
• C. Asthma
• D. Renal impairment

Answer: (A)

Tranexamic acid reduces bleeding by blocking the breakdown of clots, but this means it can promote thrombosis in people who already have a tendency to form clots. An active clotting disorder signals a higher risk that any additional clot stability from TXA could lead to harmful thromboembolic events, which is why it is a contraindication. The other conditions listed aren’t absolute blockers to TXA use: hypertension and asthma don’t inherently contraindicate it, and renal impairment mainly requires dose considerations rather than an outright ban in many cases, though severe renal impairment calls for caution.

Tranexamic acid reduces bleeding by blocking the breakdown of clots, but this means it can promote thrombosis in people who already have a tendency to form clots. An active clotting disorder signals a higher risk that any additional clot stability from TXA could lead to harmful thromboembolic events, which is why it is a contraindication. The other conditions listed aren’t absolute blockers to TXA use: hypertension and asthma don’t inherently contraindicate it, and renal impairment mainly requires dose considerations rather than an outright ban in many cases, though severe renal impairment calls for caution.